New Research Suggests Kyowa Hakko Bio’s Cognizin® Citicoline Aids in Memory Function

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Findings published in The Journal of Nutrition demonstrate supplementation of citicoline for improved overall memory performance in healthy elderly populations.

Kyowa Hakko Bio Co., Ltd, an international health ingredients manufacturer and world leader in the development, manufacturing, and marketing of pharmaceuticals, nutraceuticals and food products announced Cognizin^® Citicoline may notably improve composite memory, specifically episodic memory.

The study, titled aimed to investigate the effects of citicoline on memory in healthy elderly populations with age-associated memory impairment (AAMI). A total of 100 healthy men and women between ages 50 and 85 were evaluated as a part of this randomized, double-blind, placebo-controlled trial*¹ during an intervention period of twelve weeks. Participants were randomized to receive either a 500 mg/d dosage of citicoline or a placebo, with memory functions assessed at baseline and at the end of the intervention using standardized computerized tests. Between-group analysis indicated that the changes from baseline scores were statistically significantly different between test groups for Paired Associates, which was the outcome for episodic memory, and Composite Memory, which was the outcome for overall memory, whereby the citicoline group demonstrated greater improvements in these tests compared with the placebo group. We did not observe any serious adverse events following daily consumption of citicoline for 12 weeks.

^*1A testing methodology used in clinical trials in which participants are randomly divided into groups to receive the placebo or the actual-active ingredient, and which group is which is unknown until the trial is completed.

The study concluded that “dietary supplementation of citicoline for 12-week improved overall memory performance, especially episodic memory, in healthy older males and females with AAMI. The findings suggest that regular consumption of citicoline may be safe and potentially beneficial against memory loss due to aging.”

Eri Nakazaki, PhD, Lead Researcher at KIRIN Central Research Institute where is R&D division of Kyowa Hakko Bio’s parent company explains that, "Citicoline is a potent brain-health nutrient found in cells of the body and is especially vital to brain health and the formation of phospholipids. Citicoline also increases an important substance in the brain called phosphatidylcholine that supports healthy brain function." Cognizin^® is a branded form of Citicoline that has been clinically studied to support mental energy, focus, and attention*. "The data from this analysis is very encouraging that regular consumption, 500mg/d, of Cognizin® citicoline may be safe and potentially beneficial against memory loss due to aging."

This study contributes to the growing body of evidence that demonstrates the clear value of Cognizin^®, featured in over 200 products globally. Unlike other ingredients, Cognizin^® isn’t chemically synthesized, and is made by Kyowa Hakko’s innovative fermentation process to deliver top-quality and purity, while being vegetarian, allergen-free and self-affirmed GRAS.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.